Clinical experimental research is necessary to establish the safety and effectiveness of specific health and medical products and practices. Much of what is known today about the safety and efficacy of specific products and treatments have come from randomised controlled clinical trials designed to answer important scientific and health care questions. Randomised controlled trials form the foundation for "evidence-based medicine", but such research can be relied upon only if it is conducted according to principles and standards collectively referred to as "Good Clinical Research Practice" (GCP).

 

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The NTDs are infectious diseases that are the source of tremendous suffering because of their disfiguring, debilitating, and sometimes deadly impact. They are called neglected because they have been largely wiped out in the more developed parts of the world and persist only in the poorest, most marginalised communities and conflict areas. Social stigma is a significant consequence of NTDs. In addition to causing physical and emotional suffering, these devastating diseases hamper a person to work, keep children out of school, and prevent families and communities from thriving.
It frequently affects the poorest of the poor in poor communities in remote regions. The affected population is of low socioeconomic status, low visibility, and low political and social voice, hence they are neglected. The disease is considered a social stigma in particularly among females and children. Thus, they tend to hide it for a prolonged period, and when they are compelled to seek medical care, the condition is then at a late stage.